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In a 2021 study in obese mice, 5-amino-1MQ administration caused significant body mass reductions in the rodents, who achieved body composition and liver adiposity parameters that were comparable to the lean mice in the control group

Such differential expression suggests a fine-tuning of the Wnt pathway, where certain genes are upregulated in one structure but not the other, leading to unique phenotypic traits of hair and nails

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